https://www.nature.com/articles/s41591-021-01343-4.epdf?sharing_token=OrAyNc75rJ-Jngq6IKlRatRgN0jAjWel9jnR3ZoTv0Oo9Kj2gj0kE2bYEWztyGJe6h8lmMrtc8c3xT__EO3AoSNnL9klxiEkYDkJZLywYt79Co2rjvnY06q9Qq49SSYDddCsgakfK5roO3XT79bU4LT0Hi2aZsl20rCUFqvm_Zw%3D